All-trans retinoic acid
All-trans retinoic acid is widely used in therapeutic creams for skin disorders. Other uses are the treatment of acute promyelocytic leukemia and other forms of cancer (experimental approaches). Workers can be occupationally exposed to all-trans retinoic acid in the pharmaceutical industry, in pharmacies or in hospitals. Pregnant women exposed to all-trans retinoic acid can be at risk of developmental effects. The Subcommittee on the Classification of Reproduction Toxic Substances of the Health Council recommends classifying all-trans retinoic acid for effects on offspring development in category 1B (presumed human reproductive toxicant). For effects on parental fertility and effects on or via lactation, the Subcommittee recommends not classifying the substance due to a lack of appropriate data.