The Health Council of the Netherlands reviewed the drug phenytoin. Phenytoin is a synthetic anticonvulsant, which can be used in the treatment of most types of seizure disorders and status epilepticus. Occasionally, phenytoin is used as an antiarrhythmic drug. Man can be occupationally exposed to phenytoin in the pharmaceutical industry, in pharmacies or in hospitals. This occupational exposure may lead to adverse health effects. This report is part of a series, in which the Health Council evaluates the effects of substances on reproduction, at the request of the Minister of Social Affairs and Employment.